Concierge Longevity Medicine in NYC
Unlocking the Code of Biological Youth
Your health is one of the few true variables in life you can master — and doing so opens the door to extraordinary possibilities. At our Upper East Side practice, we deliver precision longevity protocols and healthspan optimization strategies tailored to discerning individuals seeking to decelerate biological aging and sustain cellular vitality.
We don’t just manage aging. We target its root causes.
Aging isn’t a passive process — it’s a dynamic system of molecular, metabolic, and genomic signals that can be measured, decoded, and influenced through the science of translational and regenerative medicine. We view aging as programmable, not inevitable.
Advanced Biomarker Testing & Genomic Insights
At our concierge longevity clinic in Manhattan, we integrate advanced biomarker testing, genomic analysis, and precision interventions — partnering with patients to extend their healthspan, resilience, and cognitive prime. Our strategies are designed not only to slow biological aging but to enhance physical vitality, support aesthetic youthfulness, and help you look, feel, and perform younger — thriving across decades, not just surviving them.
We offer comprehensive, multi-omic assessments to track and support biological age, metabolic resilience, and cellular function. This includes real-time physiologic monitoring, early disease detection, and molecular diagnostics that identify vulnerability before symptoms arise. Your data is translated into a personalized, actionable longevity plan — integrating genomics-informed medicine, targeted lifestyle optimization, and elite performance strategies, all delivered with the discretion and precision expected by high-net-worth individuals and global clientele.
We specialize in personalized healthspan optimization, biological age deceleration, and retrogeria strategies — merging cutting-edge biotechnology with ancestral health intelligence. This isn’t cosmetic. This isn’t conventional. It’s precision geromedicine at its most personalized and strategic.
Our Evidence-Based Approach to Healthspan Optimization
We strategically address the validated hallmarks of aging — including genomic instability, telomere attrition, epigenetic drift, mitochondrial dysfunction, cellular senescence, deregulated nutrient sensing, altered intercellular communication, stem cell exhaustion, and impaired proteostasis. Our interventions incorporate evidence-based gerotherapeutics, including NAD⁺ enhancement, mitochondrial optimization, autophagy support, and physician-directed senolytic therapies such as Qualia Senolytic, Rejuvant for AMPK activation and methylation support, Timeline for Urolithin A–driven mitochondrial health, and BROQ sulforaphane for cellular detoxification and NRF2 pathway activation. We also integrate redox-active compounds such as methylene blue, studied for its mitochondrial and cognitive-enhancing properties.
Every component of the Primas Primal Protocol™ is designed to modulate the fundamental biology of aging — enhancing mitochondrial resilience, cognitive clarity, immune system function, vascular elasticity, and musculoskeletal strength to counteract sarcopenia and frailty. Sleep optimization protocols are also embedded to promote glymphatic system clearance and neurorestoration, supporting long-term cognitive function.
The Primas Primal Protocol™ is Manhattan’s premier longevity framework — fusing genomic medicine, metabolomic profiling, evolutionary biology, and functional performance science into a personalized system. We begin by building your biological blueprint using advanced aging biomarkers, including methylation-based clocks such as DunedinPACE and PhenoAge, telomere length analysis, glycomic age profiling, and multi-system composite aging scores. Genomic and metabolomic panels allow us to interpret SNPs, assess methylation and epigenetic drift, and identify nutrient deficiencies or toxic load.
Lab work extends far beyond conventional panels — incorporating inflammatory markers like hs-CRP and IL-6, glycation end-products, insulin sensitivity and fasting insulin levels, advanced hormonal profiles, and lipid subfractionation including ApoB, Lp(a), LDL-P, and sdLDL particle size. We also include advanced cardiovascular risk stratification tools such as cholesterol efflux capacity, Lp(a) phenotyping, oxidized LDL markers, and expanded HDL functionality mapping — providing a more tailored approach to lipid management and vascular optimization. These insights are integrated with genetic and phenotypic data to guide individualized strategies for cardiometabolic performance and early atherogenic risk reduction.
We also offer the Grail Galleri multi-cancer early detection test, a clinically validated, blood-based screening that identifies active cancer signals across more than 50 cancer types — including many for which there is currently no routine early detection available.
DEXA-based body composition is assessed using the SECA mBCA Ultra, a clinical-grade, radiation-free system that rivals traditional DEXA in precision, while offering additional insights into phase angle, visceral adiposity, intracellular hydration, and segmental muscle distribution — allowing for safe, repeatable tracking across time without radiation exposure.
We support advanced performance and resilience tracking through our partnerships with New York’s premier performance laboratories. Patients have access to comprehensive diagnostics including VO₂ max evaluation, respiratory exchange ratio, lactate threshold testing, balance and proprioception assessments, grip strength, gait analysis, and force plate–based neuromuscular response metrics. VO₂ max and metabolic thresholds are used not as fitness metrics — but as aging clocks.
To complement these insights, we offer optional wearable tools such as Katalyst EMS for neuromuscular stimulation and physician-guided blood flow restriction (BFR) training to support muscle preservation, strength, and metabolic activation. We also offer Reflexion, a neurovisual training platform that enhances reaction time, visual processing, and cognitive-motor coordination — reinforcing both cognitive agility and neuroplasticity as part of a strategic longevity protocol.
Your data doesn’t live in a vacuum. We integrate continuous wearable outputs, including real-time blood glucose from CGMs, HRV recovery and readiness metrics, circadian rhythm mapping, and sleep architecture — along with data from vagal tone–supportive neuromodulation devices. This allows us to refine and adjust your protocol in real time.
We also leverage therapeutic modalities to restore regeneration, resilience, and performance. For patients interested in plasma-based therapeutics, we offer specialized referral pathways for Young Plasma and Parabiosis Protocols (YPPP) under strict, research-driven oversight. We also refer appropriate candidates to top-tier therapeutic plasmapheresis centers, focusing on metabolic rejuvenation and immunomodulation.
For neurocognitive longevity, we refer for advanced volumetric MRI analysis using NeuroQuant, along with comprehensive brain performance testing. We incorporate medical-grade photobiomodulation — including red and near-infrared light therapy — for mitochondrial support, tissue repair, and circadian regulation, and we partner with premier Hyperbaric Oxygen Therapy (HBOT) centers in New York City for vascular repair, cognitive preservation, and mitochondrial biogenesis.
We offer threshold sound conditioning therapy and proprietary auditory evaluations in-office using the Audiocardio platform. This intervention is designed to support long-term auditory resilience, enhance hearing clarity, and provide non-invasive, data-driven treatment for tinnitus. By delivering personalized neuroacoustic stimulation, Audiocardio helps retrain the auditory system and preserve central auditory processing — particularly valuable for patients with early sensory decline or those seeking cognitive and sensory longevity as part of a comprehensive plan.
What makes our approach truly distinct is the integration of ancestral and evolutionary principles into modern science. We believe that aligning with the body’s original design fosters deep, sustainable health. This includes circadian rhythm entrainment, time-restricted eating, nutrient cycling, mobility and primal movement patterns, environmental toxin avoidance and detoxification, and quantum biology — recognizing the impact of redox balance, electromagnetic signaling, and mitochondrial coherence on the aging process. We recalibrate sleep not just for rest but for active glymphatic repair and cognitive resilience. Each layer supports a coherent biological rhythm capable of resisting entropy.
We care for patients across the full lifespan. Many younger adults come to us in their 30s and 40s seeking to map a proactive, lifelong strategy that builds cellular resilience decades before disease emerges. Midlife patients often engage with us to refine their protocols, reverse metabolic and cognitive trends, and enhance physical and cognitive performance. We also care for older adults seeking to restore lost vitality, reconnect with their energy, and reengage with life. In many cases, adult children bring us in to support their parents’ cognitive health, energy, and longevity. We proudly care for thriving individuals in their 90s — and even several centenarian and supercentenarian patients — who reflect the upper edge of human potential when longevity is intentionally cultivated.
In addition to providing one-on-one care, Dr. Primas focuses on translating longevity science into practical, real-world impact — not only in clinical protocols but also in how health optimization is experienced in everyday life. He advises developers, wellness founders, and physicians on how to integrate aging biology into programs, physical environments, and personalized care pathways. Through mentorship, clinical modeling, and strategic collaboration, he helps shape the future of longevity medicine while remaining fully grounded in its present-day application.
We collaborate with some of the world’s leading researchers in longevity, regenerative medicine, and aging biology. These relationships allow our patients early access to emerging therapeutics, diagnostics, and next-generation tools long before they reach the mainstream. From translational geroscience trials to experimental therapeutics, our patients benefit from proximity to the future of medicine — always grounded in clinical rigor and guided by personal relevance.
While many emerging longevity clinics feel corporate, algorithmic, or impersonal, we remain intentionally intimate by design. Dr. Primas and his longstanding team have cultivated a reputation for deep relationships, continuity of care, and exceptional outcomes — reflected in the trust and loyalty of multi-generational families over decades. We offer strategic, personalized, high-touch care that values nuance and long-term planning, not churn.
We may occasionally recommend curated wellness tools, supplements, or technologies that support your plan. These recommendations are based solely on clinical relevance and integrity — never on financial incentive. If we maintain an affiliate relationship, it is disclosed transparently and ethically. Our clinical judgment is never compromised.
Plan B: Future Care & Transition Support
While our focus is on extending healthspan, maximizing vitality, and keeping you in peak cognitive and physical performance for as long as possible, we also believe in preparing for all eventualities. For some, this includes exploring advanced end-of-life strategies such as cryonics. We discreetly support patients who elect to work with organizations such as Alcor or the Cryonics Institute, ensuring a seamless transition during this critical moment. Our role can include medical coordination, timely documentation such as death certificates, and on-site collaboration with cryonics teams to preserve optimal conditions for their protocols.
These services are approached with sensitivity, privacy, and the same strategic precision we apply to longevity medicine — ensuring peace of mind for patients and their families. Just as with any aspect of our care, this is not about fear of the future, but about making deliberate, informed choices that align with your personal values and vision.